APA
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Devoy, A., Kalmar, B., Stewart, M., Park, H., Burke, B., Noy, S., … Fisher, E. (2017). Humanized mutant FUS drives progressive motor neuron degeneration without aggregation in ‘FUSDelta14’ knockin mice. Brain : a Journal of Neurology.
Chicago/Turabian
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Devoy, A., B. Kalmar, M. Stewart, H. Park, B. Burke, Suzanna Noy, Yushi T. Redhead, et al. “Humanized Mutant FUS Drives Progressive Motor Neuron Degeneration without Aggregation in ‘FUSDelta14’ Knockin Mice.” Brain : a journal of neurology (2017).
MLA
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Devoy, A., et al. “Humanized Mutant FUS Drives Progressive Motor Neuron Degeneration without Aggregation in ‘FUSDelta14’ Knockin Mice.” Brain : a Journal of Neurology, 2017.
BibTeX Click to copy
@article{a2017a,
title = {Humanized mutant FUS drives progressive motor neuron degeneration without aggregation in ‘FUSDelta14’ knockin mice},
year = {2017},
journal = {Brain : a journal of neurology},
author = {Devoy, A. and Kalmar, B. and Stewart, M. and Park, H. and Burke, B. and Noy, Suzanna and Redhead, Yushi T. and Humphrey, J. and Lo, K. and Jaeger, J. and Maza, Alan Mejia and Sivakumar, P. and Bertolin, C. and Soraru', G. and Plagnol, V. and Greensmith, L. and Arozena, Abraham Acevedo and Isaacs, A. and Davies, B. and Fratta, P. and Fisher, E.}
}
Devoy et al. develop the first mouse model to fully recapitulate human FUS-ALS, as defined by midlife-onset progressive degeneration of motor neurons with dominant inheritance. A toxic gain of function occurs in the absence of FUS protein aggregation, involving disturbance of ribosomes and mitochondria at the endoplasmic reticulum.